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A 77-01

Cat. No. 6712 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent inhibitor of TGF-βRI
化学名： 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 77-01

A 77-01 is a potent TGF-βRI (ALK-5) inhibitor (IC50 = 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).

化合物库 for A 77-01

A 77-01 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 77-01

分子量 286.33
公式 C18H14N4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 607737-87-1
PubChem ID 10469233
InChI Key KJTYZDORHCDZPS-UHFFFAOYSA-N
Smiles CC1=NC(C2=NNC=C2C3=CC=NC4=C3C=CC=C4)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 77-01

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.63 100
1eq. HCl 14.32 50

制备储备液 for A 77-01

以下数据基于产品分子量 286.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.46 mL 34.92 mL
5 mM 0.7 mL 3.49 mL 6.98 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for A 77-01

参考文献是支持产品生物活性的出版物。

Tojo et al (2005) The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer Sci. 96 791 PMID: 16271073

Sawyer et al (2003) Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain. J.Med.Chem. 46 3953 PMID: 12954047

If you know of a relevant reference for A 77-01, please let us know.

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关键词: A 77-01, A 77-01 supplier, A77-01, A7701, transforming, growth, factor, receptor, TGF, B, beta, β, type, I, kinase, inhibitors, inhibits, potent, p38, MAPK, A, 83-01, A83-01, TGF-beta, Receptors, BMP, and, Other, Activin, 6712, Tocris Bioscience

1 篇 A 77-01 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 77-01 的部分引用包括：

Vincent W et al (2020) Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury. Sci Rep 10 18300 PMID: 33110120

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for A 77-01

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.