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Submit ReviewAA 147
说明： ER proteostasis regulator
化学名： N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
纯度： ≥98% (HPLC)
生物活性 for AA 147
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).
化合物库 for AA 147
AA 147 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AA 147
| 分子量 | 255.31 |
| 公式 | C16H17NO2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 393121-74-9 |
| PubChem ID | 882909 |
| InChI Key | AWHLTHOHBAGPMY-UHFFFAOYSA-N |
| Smiles | CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AA 147
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.53 | 100 | |
| ethanol | 25.53 | 100 |
制备储备液 for AA 147
以下数据基于产品分子量 255.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.92 mL | 19.58 mL | 39.17 mL |
| 5 mM | 0.78 mL | 3.92 mL | 7.83 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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产品说明书 for AA 147
参考文献 for AA 147
参考文献是支持产品生物活性的出版物。
Plate et al (2016) Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 5 e15550 PMID: 27435961
If you know of a relevant reference for AA 147, please let us know.
关键词: AA 147, AA 147 supplier, AA147, proteostasis, regulators, regulates, ATF6, ER, endoplasmic, reticulum, protein, aggregation, amyloidogenesis, amyloidogenic, Other, stress/UPR, 6759, Tocris Bioscience
5 篇 AA 147 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AA 147 的部分引用包括：
Jochen H M et al (2023) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nat Commun 14 2132 PMID: 37059720
Xiaoyan et al (2022) Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes. Nat Commun 13 5859 PMID: 36216837
Yang et al (2021) Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats. Front Surg 8 665260 PMID: 34222317
Shu et al (2021) Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. J Am Heart Assoc 10 e020216 PMID: 34111943
Peng et al (2021) In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. Nat Metab 3 682-700 PMID: 34031592
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AA 147 的评论
平均评分: 5 (Based on 1 Review.)
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ATF6 activation.
By
Anonymous on 10/30/2020
分析类型： In Vitro
种属： Human
细胞系/组织： Molm13
Used to induce activation of the ATF6 ER stress pathway
Worked well, induced translocation of ATF to the nucleus (green in image), showing cleavage of the protein and its activation. Caused reduction of downstream inhibited genes CPT1a and PPARA in our experiments
