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Submit ReviewAcetyl-Calpastatin (184-210) (human)
说明： Selective calpain inhibitor
纯度： ≥95% (HPLC)
生物活性 for Acetyl-Calpastatin (184-210) (human)
Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
技术数据 for Acetyl-Calpastatin (184-210) (human)
| 分子量 | 3177.65 |
| 公式 | C142H230N36O44S |
| 序列 |
DPMSSTYIEELGKREVTIPPKYRELLA (Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 123714-50-1 |
| PubChem ID | 90488788 |
| InChI Key | ZXJCOYBPXOBJMU-HSQGJUDPSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Acetyl-Calpastatin (184-210) (human)
参考文献 for Acetyl-Calpastatin (184-210) (human)
参考文献是支持产品生物活性的出版物。
Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866 PMID: 2553724
Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377
Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70
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关键词: Acetyl-calpastatin 184-210 (human), Acetyl-calpastatin 184-210 (human) supplier, Selective, calpain, inhibitors, inhibits, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human), Calpains, 2950, Tocris Bioscience
3 篇 Acetyl-Calpastatin (184-210) (human) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Acetyl-Calpastatin (184-210) (human) 的部分引用包括：
Davis et al (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. Hypertension 1 e86355 PMID: 27158675
Gerónimo-Olvera et al (2017) Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons. Cell Death Dis 8 e2911 PMID: 28661473
Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115
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