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Submit ReviewAcyclovir
说明： Inhibits viral DNA polymerase; antiherpetic agent
别名： Aciclovir,Acycloguanosine
化学名： 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
纯度： ≥99% (HPLC)
生物活性 for Acyclovir
Acyclovir is an antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
化合物库 for Acyclovir
Acyclovir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Acyclovir
| 分子量 | 225.21 |
| 公式 | C8H11N5O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 59277-89-3 |
| PubChem ID | 2022 |
| InChI Key | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| Smiles | NC1=NC(=O)C2=C(N1)N(COCCO)C=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Acyclovir
参考文献 for Acyclovir
参考文献是支持产品生物活性的出版物。
Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868
Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734
Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716
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关键词: Acyclovir, Acyclovir supplier, Viral, DNA, polymerases, inhibitors, inhibits, antiherpetic, agent, Synthesis, antiviral, Aciclovir, Acycloguanosine, Polymerase, DNA,, RNA, and, Protein, Herpes, Simplex, Viruses, 2513, Tocris Bioscience
Acyclovir 的评论
平均评分: 4 (Based on 1 Review.)
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Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
By
Anonymous on 08/18/2019
种属： Human
Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.