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Submit ReviewAdenosine 5'-(α,β-methylene)diphosphate sodium salt
Discontinued Product
This product has been withdrawn from sale and is superseded by Adenosine 5'-(α,β-methylene)diphosphate disodium salt (Cat. No. 8173)
说明： Ecto-5'-nucleotidase (CD73) inhibitor
别名： AMPCP,APCP
化学名： α,β-Methyleneadenosine 5'-diphosphate monosodium salt
纯度： ≥98% (HPLC)
生物活性
Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.
技术数据
| 分子量 | 447.21 |
| 公式 | C11H16N5NaO9P2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 89016-30-8 |
| PubChem ID | 91691113 |
| InChI Key | RFGZKSPLJPHQMI-RDJRRFHDSA-M |
| Smiles | NC1=C2C(N([C@@H]3O[C@H](COP(CP(O)(O[Na])=O)(O)=O)[C@@H](O)[C@@H]3O)C=N2)=NC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
Niemelä et al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718 PMID: 18825744
Kur et al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491 PMID: 24277867
Ujházy et al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer. 68 493 PMID: 8945621
Chen et al (2019) Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats. ACS Chem.Neurosci. 10 2809 PMID: 30913879
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关键词: Adenosine 5'-(a,b-methylene)diphosphate sodium salt, Adenosine 5'-(a,b-methylene)diphosphate sodium salt supplier, [3768-14-7], MS, multiple, sclerosis, Ecto-5'-nucleotidase/, CD73, inhibitors, inhibits, adenosine, doxorubicin-resistance, vasoconstrictor, NT5E, eN, eNT, 5', nucleotidase, ecto-5'-NT, 5-(a,b-methylene)diphosphate, AMPCP, APCP, NTPDase, 3633, Tocris Bioscience
4 篇 Adenosine 5'-(α,β-methylene)diphosphate sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Adenosine 5'-(α,β-methylene)diphosphate sodium salt 的部分引用包括：
Yu et al (2022) Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients. Bioengineered 13 14204-14214 PMID: 35754345
Thomas et al (2020) Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation. Front Physiol 11 493 PMID: 32595514
Wu et al (2018) Borneol and α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors. Drug Deliv 25 1858 PMID: 30338713
Caiazzo et al (2016) Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem.Pharmacol. 112 72 PMID: 27188793
Adenosine 5'-(α,β-methylene)diphosphate sodium salt 的评论
平均评分: 5 (Based on 1 Review.)
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Inhibited CD73 activity in TCRgd T cells completely.
By
Anonymous on 06/05/2018
分析类型： In Vitro
种属： Mouse
Perfect for inhibiting CD73 activity in TCRgd T cells. TCRgd T cells express enzymatically active CD73 on their surface. CD73 activity was detected by the converting of AMP to adenosine which was completely blocked by APCP.
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.