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Submit ReviewAM 114
说明： 20S proteasome inhibitor
化学名： 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
纯度： ≥97% (HPLC)
生物活性 for AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).
许可信息
Sold with the permission of Johns Hopkins University
技术数据 for AM 114
| 分子量 | 377.01 |
| 公式 | C20H21B2NO5 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 856849-35-9 |
| PubChem ID | 11639443 |
| InChI Key | SRPIKXGUPAKTIZ-OTYYAQKOSA-N |
| Smiles | O=C(/C(CN(C)C3)=C/C2=CC=C(B(O)O)C=C2)/C3=C/C1=CC=C(B(O)O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM 114
参考文献 for AM 114
参考文献是支持产品生物活性的出版物。
Achanta et al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426 PMID: 16636137
Achanta et al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res.Abstr. 46 6162
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关键词: AM 114, AM 114 supplier, 20S, proteasome, inhibitors, inhibits, Proteinases, Proteases, AM114, Proteasome, 2564, Tocris Bioscience
1 篇 AM 114 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AM 114 的部分引用包括：
Dasgupta et al (2014) Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells. PLoS One 9 e103604 PMID: 25079948
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia