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Anle138b

Cat. No. 6861 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
化学名： 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Anle138b

Anle138b is an oligomeric aggregation inhibitor that inhibits formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrPSc in brain and spleen, and prolongs survival of prion-infected mice. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.

技术数据 for Anle138b

分子量 343.18
公式 C16H11BrN2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 882697-00-9
PubChem ID 44608289
InChI Key RCQIIBJSUWYYFU-UHFFFAOYSA-N
Smiles BrC1=CC=CC(=C1)C1=CC(=NN1)C1=CC=C2OCOC2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Anle138b

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.16 50

制备储备液 for Anle138b

以下数据基于产品分子量 343.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.83 mL 29.14 mL 58.28 mL
2.5 mM 1.17 mL 5.83 mL 11.66 mL
5 mM 0.58 mL 2.91 mL 5.83 mL
25 mM 0.12 mL 0.58 mL 1.17 mL

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参考文献 for Anle138b

参考文献是支持产品生物活性的出版物。

Wagner et al (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 125 795 PMID: 23604588

If you know of a relevant reference for Anle138b, please let us know.

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关键词: Anle138b, Anle138b supplier, oligomeric, aggregation, inhibitors, inhibits, prions, PrPSc, alpha, alfa, α, synuclein, synucleinopathies, brain, penetrant, Parkinson's, disease, parkinsons, neuroprotective, Prion, Protein, 6861, Tocris Bioscience

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Pathways for Anle138b

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.