AP 1867

Cat. No. 6207 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective binding ligand for FKBP12^F36V

化学名： (1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AP 1867

AP 1867 is a selective binding ligand for the single point mutant of FKBP12^F36V (IC₅₀ = 1.8 nM). Functionalized with a carboxylic acid group at the meta-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with the compound's binding ability.

技术数据 for AP 1867

分子量	693.79
公式	C₃₈H₄₇NO₁₁
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	195514-23-9
PubChem ID	444590
InChI Key	XCCRAOPQCACRFC-OIFRRMEBSA-N
Smiles	O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(O)=O)=CC=C3)CCC4=CC(OC)=C(OC)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AP 1867

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	69.38	100
	DMSO	69.38	100

制备储备液 for AP 1867

以下数据基于产品分子量 693.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.41 mL
5 mM	0.29 mL	1.44 mL	2.88 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

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产品说明书 for AP 1867

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AP 1867

参考文献是支持产品生物活性的出版物。

Koide et al (2001) A synthetic library of cell-permeable molecules. J.Am.Chem.Soc. 123 398 PMID: 11456541

Clackson et al (1998) Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.U.S.A. 95 10437 PMID: 9724721

If you know of a relevant reference for AP 1867, please let us know.

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关键词: AP 1867, AP 1867 supplier, AP1867, dTAG, FKBP, FK506, building, block, chemical, biology, FKBP12, FKBP12F36V, onward, chemistry, carboxylic, acid, group, TAG, Degradation, Platform, 6207, Tocris Bioscience

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product GuideUpdated

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