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Submit ReviewJP-2-196 alkyne New
Description: RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).
Chemical Name: 1-(4-Methoxyphenyl)-4-[4-(2-propyn-1-yl)-1-piperazinyl]-2-butene-1,4-dione
Purity: ≥95% (HPLC)
Biological Activity for JP-2-196 alkyne
JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders. JP-2-196 alkyne is an alkyne functionalized version of JP-2-196 (Cat. No. 8046).
Technical Data for JP-2-196 alkyne
| M. Wt | 312.37 |
| Formula | C18H20N2O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2901113-25-3 |
| PubChem ID | 167740300 |
| InChI Key | COPXSSDNGLPYDY-CMDGGOBGSA-N |
| Smiles | O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCN(CC2)CC#C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JP-2-196 alkyne
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.24 | 100 |
Preparing Stock Solutions for JP-2-196 alkyne
The following data is based on the product molecular weight 312.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16.01 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets for JP-2-196 alkyne
References for JP-2-196 alkyne
References are publications that support the biological activity of the product.
Toriki et al (2023) Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 9 915 PMID: 37252349
If you know of a relevant reference for JP-2-196 alkyne, please let us know.
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Keywords: JP-2-196 alkyne, JP-2-196 alkyne supplier, JP2-196, alkyne, e3, ligase, RNF126, ligands, targeted, protein, TPD, Degrader, Degraders, molecular, glue, Ubiquitin, E3, Ligases, Molecular, Glues, 8047, Tocris Bioscience
Citations for JP-2-196 alkyne
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia