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Description: RNF126 chemical handle
Chemical Name: 1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione hydrochloride
Purity: ≥95% (HPLC)
Biological Activity for JP-2-196
JP-2-196 is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM. By facilitating E3 ligase recruitment, JP-2-196 induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders.
Usage Guidelines for JP-2-196
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for JP-2-196
| M. Wt | 310.78 |
| Formula | C15H18N2O3.HCl |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | KITOUXXMDYKXJY-UHDJGPCESA-N |
| Smiles | O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCNCC2)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JP-2-196
References for JP-2-196
References are publications that support the biological activity of the product.
Toriki et al (2023) Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 9 915 PMID: 37252349
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Keywords: JP-2-196, JP-2-196 supplier, JP2-196, e3, ligase, RNF114, ligands, targeted, protein, TPD, Degrader, Degraders, molecular, glue, Ubiquitin, E3, Ligases, Molecular, Glues, 8046, Tocris Bioscience
Citations for JP-2-196
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia