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AP 1903

Cat. No. 6130 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Chemical inducer of protein dimerization; active in vivo
化学名： 2,2'-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AP 1903

AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBPF36V and intracellular domain of Fas receptor with high potency (EC50 = 0.1 nM). Exhibits >50-fold selectivity for FKBPF36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active in vivo.

技术数据 for AP 1903

分子量 1411.65
公式 C78H98N4O20
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 195514-63-7
PubChem ID 16135625
InChI Key GQLCLPLEEOUJQC-ZTQDTCGGSA-N
Smiles O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C4)=O)=O)=CC=C3)CCC8=CC(OC)=C(OC)C=C8

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AP 1903

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 141.16 100
ethanol 141.16 100

制备储备液 for AP 1903

以下数据基于产品分子量 1411.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.71 mL 3.54 mL 7.08 mL
5 mM 0.14 mL 0.71 mL 1.42 mL
10 mM 0.07 mL 0.35 mL 0.71 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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参考文献 for AP 1903

参考文献是支持产品生物活性的出版物。

Clackson et al (1998) Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.USA. 95 10437 PMID: 9724721

Gargett & Brown (2014) The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Front.Pharmacol. 5 235 PMID: 25389405

If you know of a relevant reference for AP 1903, please let us know.

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关键词: AP 1903, AP 1903 supplier, AP1903, Chemical, protein, dimerizer, iCas9, inducible, caspase, 9, suicide, gene, induces, inducers, apoptosis, FKBPF36V, fusion, FK506-binding, Protein, Dimerizers, 6130, Tocris Bioscience

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