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Description: Dlin-MC3 containing LNP for in vitro and in vivo deliver of luciferase mRNA
Biological Activity for MC3 LNP Luciferase
MC3 LNP Luciferase is a fully formulated lipid nanoparticle (LNP) composed of DLin-MC3-DMA, DSPC, cholesterol, DMGPEG2000 with the molar ratio 50:10:38.5:1.5.11 providing a convenient, ready to use, benchmark LNP formulation. Contains a reporter luciferase mRNA for in vitro and in vivo bioluminescence detection when used with D-luciferin (Cat. No. 5117).
Do not use a vortex to resuspend LNPs as this can disrupt the lipid membrane and damage particle integrity.
Technical Data for MC3 LNP Luciferase
| Storage | Store at -80°C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MC3 LNP Luciferase
| Solubility | Soluble in TBS buffer solution (10% sucrose, pH 7.5). Supplied in 200 µL aliquots, 0.05 µg/µL RNA concentration |
Product Datasheets for MC3 LNP Luciferase
References for MC3 LNP Luciferase
References are publications that support the biological activity of the product.
Brown et al (2024) Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles. Cell 187 5357 PMID: 39260374
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Citations for MC3 LNP Luciferase
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