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Submit ReviewDSPE-PEG 2000 Azide New
Description: PEGylated DSPE with azide reactive group
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-azido(polyethyleneglycol)-2000]
Purity: ≥90% (HPLC)
Biological Activity for DSPE-PEG 2000 Azide
DSPE-PEG 2000 Azide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (Mr 2000) with an azide-terminated end for onward chemistry. It is commonly used to synthesize antibody-coupled liposomes and lipid nanoparticles. It has been used to make macrophage and EGFR antibody targeted LNPs using strain-promoted azide alkyne cycloaddition (SPAAC) click reaction.
Technical Data for DSPE-PEG 2000 Azide
| Formula | (C2H4O)nC44H84N4O10P.NH4 |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 1938081-40-3 |
| PubChem ID | 168311704 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DSPE-PEG 2000 Azide
| Solubility | Soluble to 10 mg/ml in ethanol and to 10 mg/ml in chloroform |
Product Datasheets for DSPE-PEG 2000 Azide
References for DSPE-PEG 2000 Azide
References are publications that support the biological activity of the product.
Zhao et al (2024) Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proc.Natl.Acad.Sci.U.S.A. 13 e2314747121 PMID: 38315853
Geisler et al (2024) EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. J.Control Release 371 455 PMID: 38789090
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