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AP 20187

Cat. No. 6297 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Chemical inducer of protein dimerization; active in vivo
化学名： 2,2'-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AP 20187

AP 20187 is a chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.

For more information about how AP 20187 may be used, see our protocol.

技术数据 for AP 20187

分子量 1482.77
公式 C82H107N5O20
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 195514-80-8
PubChem ID 78357784
InChI Key NSBGUMKAXUXKGI-BPNHAYRBSA-N
Smiles O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCC(CN(C)C)CNC(COC4=CC=CC([C@H](OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C4)=O)=O)=CC=C3)CCC8=CC(OC)=C(OC)C=C8

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AP 20187

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 148.28 100
ethanol 148.28 100

制备储备液 for AP 20187

以下数据基于产品分子量 1482.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.37 mL 6.74 mL
5 mM 0.13 mL 0.67 mL 1.35 mL
10 mM 0.07 mL 0.34 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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产品说明书 for AP 20187

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AP 20187

参考文献是支持产品生物活性的出版物。

Shariat et al (2001) Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. Cancer Res. 61 2562 PMID: 11289132

Baker et al (2016) Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530 184 PMID: 26840489

Ono (2017) Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes. PLoS One 12 e0173176 PMID: 28257518

Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496

If you know of a relevant reference for AP 20187, please let us know.

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关键词: AP 20187, AP 20187 supplier, AP20187, Chemical, protein, dimerizer, caspases, 9, induces, inducers, apoptosis, FKBPF36V, fusion, FK506-binding, CID, Protein, Dimerizers, 6297, Tocris Bioscience

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