Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAphidicolin
说明： DNA polymerase α, δ and ε inhibitor
化学名： (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
纯度： ≥98% (HPLC)
生物活性 for Aphidicolin
Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.
技术数据 for Aphidicolin
| 分子量 | 338.48 |
| 公式 | C20H34O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 38966-21-1 |
| PubChem ID | 457964 |
| InChI Key | NOFOAYPPHIUXJR-APNQCZIXSA-N |
| Smiles | OC[C@@]1(O)CC[C@@]23[C@](CC[C@]4([H])[C@]3(C)CC[C@@H](O)[C@@]4(C)CO)([H])C[C@@H]1C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Aphidicolin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 8.46 | 25 |
制备储备液 for Aphidicolin
以下数据基于产品分子量 338.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.82 mL | 59.09 mL | 118.18 mL |
| 1.25 mM | 2.36 mL | 11.82 mL | 23.64 mL |
| 2.5 mM | 1.18 mL | 5.91 mL | 11.82 mL |
| 12.5 mM | 0.24 mL | 1.18 mL | 2.36 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Aphidicolin
参考文献 for Aphidicolin
参考文献是支持产品生物活性的出版物。
Spadari et al (1984) Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 12 143 PMID: 11478315
Bucknall et al (1973) Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 4 294 PMID: 4357181
Syväoja et al (1990) DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 87 6664 PMID: 1975694
If you know of a relevant reference for Aphidicolin, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Aphidicolin, Aphidicolin supplier, DNA, polymerase, alpha, α, delta, δ, epsilon, ε, inhibitors, inhibits, antimitotic, antibiotic, antiviral, Polymerase, DNA,, RNA, and, Protein, Synthesis, Antibiotics, Mitosis, Non-selective, Antivirals, 5736, Tocris Bioscience
1 篇 Aphidicolin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Aphidicolin 的部分引用包括：
Clifford J et al (2019) Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development. Cell 179 90-105.e21 PMID: 31539501
您是否知道使用了 Tocris Aphidicolin 的优秀论文？ 请告知我们.
Aphidicolin 的评论
目前没有该产品的评论。 Be the first to review Aphidicolin and earn rewards!
Have you used Aphidicolin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.