Aprotinin

Cat. No. 4139 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Competitive serine protease inhibitor

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Aprotinin

Aprotinin is a competitive serine protease inhibitor. Reversibly binds to and blocks the enzymatic active site. Inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells.

This product is from Bovine Lung.

技术数据 for Aprotinin

分子量	6511.48
公式	C₂₈₄H₄₃₂N₈₄O₇₉S₇
序列	RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA (Modifications: Disulfide bridges: 5-55, 14-38, 30-51)
储存	Store at +4°C
CAS Number	9087-70-1
PubChem ID	53487898
InChI Key	ZPNFWUPYTFPOJU-YSFZTAPISA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC3=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N2)NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Aprotinin

溶解性	Soluble to 4 mg/ml in water

产品说明书 for Aprotinin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Aprotinin

参考文献是支持产品生物活性的出版物。

Parlee et al (2012) Elastase and tryptase govern TNFa-mediated production of active chemerin by adipocytes. PLoS ONE 7 e51072 PMID: 23227233

Reichel et al (2011) Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. PLoS ONE 6 e17229 PMID: 21364954

Bojkova et al (2020) SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles. Bioinformatics 37 2282

If you know of a relevant reference for Aprotinin, please let us know.

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关键词: Aprotinin, Aprotinin supplier, Aprotinin, serine, protease, inhibitors, inhibits, trypsin, plasmin, chymotrypsin, kallikrein, SARS-CoV-2, COVID-19, severe, acute, respiratory, syndrome, TMPRSS2, Other, Proteases, 4139, Tocris Bioscience