主页 / 细胞生物学 / Signal Transduction / Cytokine and NF-κB Signaling / STATs / STAT Inhibitors / AS 1517499

AS 1517499

Cat. No. 7636 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： STAT6 inhibitor
化学名： 2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AS 1517499

AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM). In vitro, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.

技术数据 for AS 1517499

分子量 397.86
公式 C20H20ClN5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 919486-40-1
PubChem ID 10340781
InChI Key OZRMEKAUZBKTTC-UHFFFAOYSA-N
Smiles O=C(N)C1=CN=C(N=C1NCC=2C=CC=CC2)NCCC3=CC=C(O)C(Cl)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AS 1517499

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.89 50
ethanol 3.98 10

制备储备液 for AS 1517499

以下数据基于产品分子量 397.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.03 mL 25.13 mL 50.27 mL
2.5 mM 1.01 mL 5.03 mL 10.05 mL
5 mM 0.5 mL 2.51 mL 5.03 mL
25 mM 0.1 mL 0.5 mL 1.01 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for AS 1517499

参考文献是支持产品生物活性的出版物。

Chiba et al (2009) A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am.J.Respir.Cell Mol.Biol. 41 516 PMID: 19202006

Nagashima et al (2008) Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine- 5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg.Med.Chem. 16 6509 PMID: 18534856

Nagashima et al (2007) Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg.Med.Chem. 15 1044 PMID: 17071093

If you know of a relevant reference for AS 1517499, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 STAT Inhibitors

关键词: AS 1517499, AS 1517499 supplier, AS1517499, STAT6, inhibitors, inhibits, In, vivo, potent, asthma, STAT, 7636, Tocris Bioscience

篇 AS 1517499 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 AS 1517499 的引用文献。 您是否知道使用了 Tocris AS 1517499 的优秀论文？ 请告知我们.

AS 1517499 的评论

目前没有该产品的评论。 Be the first to review AS 1517499 and earn rewards!

Have you used AS 1517499?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for AS 1517499

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.