JAK-STAT Signaling Pathway

Pathway Key Download PDF

Ras Raf MEK ERK1/2 ERK1/2 Cytokines RTK EGFR JAK JAK JAK mTOR Akt STAT STAT STAT STAT STAT STAT Myc Bcl-XL PI3K Src Apoptosis Proteasome Cytokine
Receptor

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. In addition to their action on STATs, JAKs activate additional signaling molecules which leads to crossover with other pathways such as MAPK and Akt.

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Signaling Pathway Key

Stimulates

Inhibits

Multistep Activation

Kinase

Enzyme-linked Receptor

Transcription Factor

Other Protein

Prosurvival