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说明： Potent ROCK inhibitor; orally bioavailable
化学名： N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea
纯度： ≥99% (HPLC)
生物活性 for AS 1892802
AS 1892802 is a potent, ATP-competitive ROCK inhibitor (IC50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.
技术数据 for AS 1892802
| 分子量 | 333.38 |
| 公式 | C20H19N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 928320-12-1 |
| PubChem ID | 46911016 |
| InChI Key | WDTFYYZHMRBVHK-LJQANCHMSA-N |
| Smiles | O=C(N[C@H](CO)C3=CC=CC=C3)NC(C=C2)=CC=C2C1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AS 1892802
参考文献 for AS 1892802
参考文献是支持产品生物活性的出版物。
Li et al (2012) Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J.Med.Chem. 55 2474 PMID: 22272748
Yoshimi et al (2010) Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J.Pharmacol.Exp.Ther. 334 955 PMID: 20534789
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关键词: AS 1892802, AS 1892802 supplier, AS1892802, rho, kinases, ROCK1, ROCK2, potent, selective, inhibitors, inhibits, ATP, competitive, pain, analgesics, analgesia, chronic, arthritis, antiinflammatory, MIA, AIA, orally, bioavailable, Rho-kinases, 4927, Tocris Bioscience
1 篇 AS 1892802 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AS 1892802 的部分引用包括：
Alexandra E et al (2017) Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chem Biol 24 858-869.e5 PMID: 28669525
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