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ASP 3026

Cat. No. 5310 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
化学名： N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ASP 3026

ASP 3026 is a potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.

化合物库 for ASP 3026

ASP 3026 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ASP 3026

分子量 580.74
公式 C29H40N8O3S
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 1097917-15-1
PubChem ID 25134326
InChI Key MGGBYMDAPCCKCT-UHFFFAOYSA-N
Smiles CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=NC=N4)C(OC)=C3)CC2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ASP 3026

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.61 20

制备储备液 for ASP 3026

以下数据基于产品分子量 580.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 8.61 mL 43.05 mL 86.1 mL
1 mM 1.72 mL 8.61 mL 17.22 mL
2 mM 0.86 mL 4.3 mL 8.61 mL
10 mM 0.17 mL 0.86 mL 1.72 mL

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参考文献 for ASP 3026

参考文献是支持产品生物活性的出版物。

George et al (2014) The ALK inhibitor ASP3026 eradicates NPM-ALK+ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget 5 5750 PMID: 25026277

Awad and Shaw (2014) ALK Inhibitors in Non-Small Cell Lung Cancer: Crizotinib and Beyond. Clin.Adv.Hematol.Oncol. 12 429 PMID: 25322323

Mori et al (2014) The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice. Mol.Cancer Ther. 13 329 PMID: 24419060

If you know of a relevant reference for ASP 3026, please let us know.

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