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aTAG 2139-NEG

Cat. No. 7575 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Negative control for aTAG 2139 (Cat. No. 6970)
化学名： 6-(6-((4-(2-((2-(1-Methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
实验方案 (1)
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for aTAG 2139-NEG

aTAG 2139-NEG is the negative control for aTAG 2139 (Cat. No. 6970).

技术数据 for aTAG 2139-NEG

分子量 796.84
公式 C43H40N8O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2758431-99-9
InChI Key COVBVFLLJYMIDR-UHFFFAOYSA-N
Smiles CNC(C1=C(NC2=CC=CC=C2)C3=CC(C(C=N4)=CC=C4C(NCCCCNC(COC5=C(C(N(C6C(N(C)C(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)=O)=CC=C3N=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for aTAG 2139-NEG

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 79.68 100

制备储备液 for aTAG 2139-NEG

以下数据基于产品分子量 796.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.25 mL 6.27 mL 12.55 mL
5 mM 0.25 mL 1.25 mL 2.51 mL
10 mM 0.13 mL 0.63 mL 1.25 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

Calculate the dilution required to prepare a stock solution.
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参考文献 for aTAG 2139-NEG

参考文献是支持产品生物活性的出版物。

Veits et al (2021) Development of an AchillesTAG degradation system and its application to control CAR-T activity. Curr.Res.Chem.Biol. 1 100010

If you know of a relevant reference for aTAG 2139-NEG, please let us know.

按标靶查看相关产品

关键词: aTAG 2139-NEG, aTAG 2139-NEG supplier, aTAG2139, CFT2139, atag, Achilles, heel, degraders, degradation, MTH1, fusion, protein, PROTAC, proteolysis, targeting, chimeras, targeted, TPD., Negative, control, TAG, Degradation, Platform, 7575, Tocris Bioscience

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引用文献是使用了 Tocris 产品的出版物。

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aTAG 2139-NEG 实验方案

以下实验方案包含使用 aTAG 2139-NEG（目录编号 7575）的更多信息。

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia

Validating Targets for TPD Using dTAG Poster

Validating Targets for TPD Using dTAG Poster

The dTAG platform offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI) and is a useful strategy for exploration and validation of targets. This poster presents a workflow solution for target validation, from custom TAG knock-in cell-lines for your POI, different dTAG Degraders to knockdown you POI, to automated assays for protein degradation using Simple WesternTM instruments. Data are also presented on the use of an antibody that recognizes the TAG domain (FKBP12F36V) for detection of degradation. Presented at TPD Europe, March 2022, London, UK.