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Atovaquone

Cat. No. 6358 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6358 has been discontinued.

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说明： Inhibits complex III of mitochondrial electron transport chain in parasites
化学名： 2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Atovaquone

Broad spectrum antiparasitic and antipneumocystic compound. Inhibits bc1 complex (complex III) of mitochondrial electron transport chain (EC50 = 0.26 μM), causing cell death in Plasmodium yoelii infected erythrocytes. Also inhibits DHODH. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.72 μM).

技术数据 for Atovaquone

分子量 366.84
公式 C22H19ClO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 95233-18-4
PubChem ID 74989
InChI Key BSJMWHQBCZFXBR-UHFFFAOYSA-N
Smiles O=C1C(O)=C([C@H]2CC[C@H](C3=CC=C(Cl)C=C3)CC2)C(C4=CC=CC=C41)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Atovaquone

参考文献是支持产品生物活性的出版物。

Hughes et al (1990) Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis. Antimicrob.Agents Chemother. 34 225 PMID: 2327770

Srivastava et al (1997) Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J.Biol.Chem. 272 3961 PMID: 9020100

Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed

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关键词: Atovaquone, Atovaquone supplier, atovaquone, antimalarial, antiparasitic, mitochondria, respiration, inhibitors, inhibits, DHODH, dihydroorotate, dehydrogenase, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, MERS, Oxidative, Phosphorylation, Dihyroorotate, Dehydrogenase, Antimalarials, Coronavirus, 6358, Tocris Bioscience

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