Autocamtide-2-related inhibitory peptide

Cat. No. 1688 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective CaM kinase II inhibitor

别名： AIP

纯度： ≥95% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC₅₀ = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC₅₀ > 10 μM).

Cell permeable derivative also available.

技术数据

分子量	1497.76
公式	C₆₄H₁₁₆N₂₂O₁₉
序列	KKALRRQEAVDAL
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	167114-91-2
PubChem ID	25031982
InChI Key	USSJDGBHUQEJJG-HKDQSZHBSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶解性	Soluble to 1 mg/ml in water

产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114

Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163 PMID: 7836445

Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca²⁺ mobilization. J.Biol.Chem. 270 30257 PMID: 8530441

If you know of a relevant reference for Autocamtide-2-related inhibitory peptide, please let us know.

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关键词: Autocamtide-2-related inhibitory peptide, Autocamtide-2-related inhibitory peptide supplier, Selective, CaM, kinase, II, inhibitors, inhibits, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, AIP, Kinase, 1688, Tocris Bioscience

2 篇 Autocamtide-2-related inhibitory peptide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Autocamtide-2-related inhibitory peptide 的部分引用包括：

Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165 PMID: 23055486

Grey and Burrell (2010) Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases. J Neurophysiol 103 2737 PMID: 20457859

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