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Submit ReviewAutocamtide-2-related inhibitory peptide, myristoylated
Description: CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide
Alternative Names: Myr-AIP,AIP Myristoylated
Purity: ≥95% (HPLC)
Biological Activity
Autocamtide-2-related inhibitory peptide, myristoylated is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide (Cat No. 1688). Pretreatment blocks reinstatement of morphine-seeking behavior in vivo.
Technical Data
| M. Wt | 1708.12 |
| Formula | C78H142N22O20 |
| Sequence |
KKALRRQEAVDAL (Modifications: Lys-1 = Myr-Lys) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 201422-04-0 |
| PubChem ID | 121513908 |
| InChI Key | QKOOKZWMKXOQRL-YJDHHEDVSA-N |
| Smiles | [H]N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Laabich et al (2000) Neuroprotective effect of AIP on N-methyl-D-aspartate-induced cell death in retinal neurons. Brain Res.Mol.Brain Res. 85 32 PMID: 11146104
Liu et al (2012) Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats. Neurosci.Lett. 518 167 PMID: 22579819
Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114
If you know of a relevant reference for Autocamtide-2-related inhibitory peptide, myristoylated, please let us know.
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Keywords: Autocamtide-2-related inhibitory peptide, myristoylated, Autocamtide-2-related inhibitory peptide, myristoylated supplier, Calmodulin-dependent, protein, kinases, CaM, kinase-II, inhibitors, inhibits, addiction, cell, permeable, Myr-AIP, AIP, Myristoylated, Kinase, Calcium, Binding, Protein, 5959, Tocris Bioscience
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