B02

Cat. No. 6392 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： RAD51 recombinase inhibitor

化学名： 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for B02

B02 is a RAD51 recombinase inhibitor, exhibiting selectivity for human RAD51 over the E.coli homologue RecA (IC₅₀ values are 27.4 μM and >250 μM, respectively). Inhibits homologous recombination and increases cellular sensitivity to DNA damage in vitro. Enhances the therapeutic effect of cisplatin (Cat. No. 2251) on tumor cells in vivo.

技术数据 for B02

分子量	339.4
公式	C₂₂H₁₇N₃O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1290541-46-6
PubChem ID	5738263
InChI Key	GEKDQXSPTHHANP-OUKQBFOZSA-N
Smiles	O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=CC=CC=C41

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for B02

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.94	100
	ethanol	3.39	10

制备储备液 for B02

以下数据基于产品分子量 339.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.73 mL	29.46 mL
5 mM	0.59 mL	2.95 mL	5.89 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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产品说明书 for B02

分析证书/产品说明书

化学品安全技术说明书

参考文献 for B02

参考文献是支持产品生物活性的出版物。

Huang et al (2011) Identification of specific inhibitors of human RAD51 recombinase using high-throughputscreening. ACS Chem.Biol. 6 682 PMID: 21428443

Huang et al (2012) Inhibition of homologous recombination in human cells by targeting RAD51 recombinase. J.Med.Chem. 55 3011 PMID: 22380680

Alagpulinsa et al (2014) A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to dox. Front.Oncol. 4 289 PMID: 25401086

Huang and Mazin (2014) A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeuticagents in mouse xenografts. PLoS One 9 e100993 PMID: 24971740

If you know of a relevant reference for B02, please let us know.

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关键词: B02, B02 supplier, B02, RAD51, recombinase, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, 6392, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

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B02