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Balicatib

Cat. No. 5585 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective cathepsin K inhibitor
化学名： N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Balicatib

Balicatib is a potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.

化合物库 for Balicatib

Balicatib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Balicatib

分子量 411.54
公式 C23H33N5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 354813-19-7
PubChem ID 10201696
InChI Key LLCRBOWRJOUJAE-UHFFFAOYSA-N
Smiles O=C(NC1(CCCCC1)C(NCC#N)=O)C(C=C2)=CC=C2N3CCN(CCC)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Balicatib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.15 100

制备储备液 for Balicatib

以下数据基于产品分子量 411.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Balicatib

参考文献是支持产品生物活性的出版物。

Desmarais et al (2008) Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 73 147 PMID: 17940194

If you know of a relevant reference for Balicatib, please let us know.

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关键词: Balicatib, Balicatib supplier, cathepsins, K, inhibitors, potent, selective, inhibits, Cathepsin, 5585, Tocris Bioscience

1 篇 Balicatib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Balicatib 的部分引用包括：

Ting et al (2021) Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway. Cells 10 PMID: 34831087

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