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Bay 11-7085

Cat. No. 1743 6 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
别名： Bay 11-7083
化学名： (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (6)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bay 11-7085

Bay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

化合物库 for Bay 11-7085

Bay 11-7085 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Bay 11-7085

分子量 249.33
公式 C13H15NO2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 196309-76-9
PubChem ID 5353432
InChI Key VHKZGNPOHPFPER-ONNFQVAWSA-N
Smiles CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bay 11-7085

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 24.93 100
DMSO 24.93 100

制备储备液 for Bay 11-7085

以下数据基于产品分子量 249.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.11 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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产品说明书 for Bay 11-7085

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Bay 11-7085

参考文献是支持产品生物活性的出版物。

Hu et al (2001) An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 61 6290 PMID: 11507084

Pierce et al (1997) Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096 PMID: 9261113

Scaife et al (2002) Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 62 6870 PMID: 12460901

If you know of a relevant reference for Bay 11-7085, please let us know.

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关键词: Bay 11-7085, Bay 11-7085 supplier, Irreversible, inhibitors, inhibits, TNF-α, TNF-alpha-induced, IκB, IκBα, IkappaBalpha, phosphorylation, IkappaB, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, NF-kB, Cytokine, Signaling, Signalling, Transcription, Factors, Bay11-7085, Bay117083, Bay, 11-7083, NF-kB/IkB, 1743, Tocris Bioscience

6 篇 Bay 11-7085 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bay 11-7085 的部分引用包括：

Clark et al (2015) Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases. PLoS One 10 e0120075 PMID: 25816133

Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097 PMID: 23404867

Hussain et al (2012) Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS One 7 e39945 PMID: 22768179

Kwon et al (2014) Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun 5 4416 PMID: 25048699

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Pathways for Bay 11-7085

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.