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BAY 805

Cat. No. 7984 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective inhibitor of USP21; also NF-κB activator
化学名： N-[(1R)-1-[[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)cyclohexanecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 805

BAY 805 is a potent and selective inhibitor of USP21 (IC50 = 6 nM, Kd = 2.2 nM). BAY 805 induces NF-κB activation (EC50= 17 nM in a cell-based reporter assay).

技术数据 for BAY 805

分子量 507.58
公式 C24H28F3N5O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2925481-88-3
PubChem ID 167312463
InChI Key LXRBPWHQMGKMRT-GOSISDBHSA-N
Smiles N#CC(C=C1)=CC=C1CC2=NN=C(S2)NC([C@@H](CC(C)C)NC(C3(CCCCC3)C(F)(F)F)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 805

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.76 100
ethanol 50.76 100

制备储备液 for BAY 805

以下数据基于产品分子量 507.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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参考文献 for BAY 805

参考文献是支持产品生物活性的出版物。

Göricke et al (2023) Discovery and characterization of BAY-805, a potent and selective inhibitor of ubiquitin-specific protease USP21. J.Med.Chem 66 3431 PMID: 36802665

If you know of a relevant reference for BAY 805, please let us know.

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关键词: BAY 805, BAY 805 supplier, BAY805, inhibitors, inhibits, potent, selective, ubiquitin, specific-processing, protease, ubiquitination, enzymes, deubiquitinating, NF-κB, activation, Deubiquitinating, Enzymes, NF-kB/IkB, 7984, Tocris Bioscience

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