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BDY FL Lenalidomide

Cat. No. 7857 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluorescent cereblon ligand
化学名： 3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexyl)propanamide
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BDY FL Lenalidomide

BDY FL Lenalidomide is a fluorescent cereblon ligand. It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 506 and 508 nm, respectively.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Optical Data for BDY FL Lenalidomide

BDY FL Lenalidomide Dye Spectra
Emission Color Green
λabs 506 nm
λem 508 nm
Closest Laser line 488 nm
Cell Permeable Yes
Application TR-FRET and FP Assays
Alternative For BDY FL Thalidomide

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectral Viewer

Spectral Viewer

技术数据 for BDY FL Lenalidomide

分子量 632.52
公式 C33H39BF2N6O4
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key RCUBMUCPIXRRKQ-UHFFFAOYSA-N
Smiles O=C(CCC1N2C(C3=C(C2)C(NCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=CC=C3)=O)NC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BDY FL Lenalidomide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.33 10

制备储备液 for BDY FL Lenalidomide

以下数据基于产品分子量 632.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 15.81 mL 79.05 mL 158.1 mL
0.5 mM 3.16 mL 15.81 mL 31.62 mL
1 mM 1.58 mL 7.9 mL 15.81 mL
5 mM 0.32 mL 1.58 mL 3.16 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for BDY FL Lenalidomide

分析证书/产品说明书
化学品安全技术说明书

参考文献 for BDY FL Lenalidomide

参考文献是支持产品生物活性的出版物。

Wang et al (2021) Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol. 17 711 PMID: 34035522

If you know of a relevant reference for BDY FL Lenalidomide, please let us know.

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该领域的文献

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