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BDY FL Thalidomide

Cat. No. 7633 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity fluorescent probe for TR-FRET cereblon binding assay
化学名： 3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)propenamide
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BDY FL Thalidomide

BDY FL Thalidomide is a high-affinity fluorescent probe (Kd = 3.6 nM). It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 502 and 510 nm, respectively.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Optical Data for BDY FL Thalidomide

BDY FL Thalidomide Dye Spectra
λabs 502 nm
λem 510 nm
Closest Laser line 488 nm
Application Time-resolved fluorescence energy transfer (TR-FRET)
Alternative For FAM; Alexa Fluor 488; DyLight 488; Cy2

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company.

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectral Viewer

Spectral Viewer

技术数据 for BDY FL Thalidomide

分子量 732.59
公式 C37H43BF2N6O7
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2740620-18-0
PubChem ID 165714709
InChI Key CJILTFJYYOHLGA-UHFFFAOYSA-N
Smiles O=C(CCC1N2C(C3=C(C2=O)C(OCC(NCCCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=O)=CC=C3)=O)NC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BDY FL Thalidomide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.33 10

制备储备液 for BDY FL Thalidomide

以下数据基于产品分子量 732.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 13.65 mL 68.25 mL 136.5 mL
0.5 mM 2.73 mL 13.65 mL 27.3 mL
1 mM 1.37 mL 6.83 mL 13.65 mL
5 mM 0.27 mL 1.37 mL 2.73 mL

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产品说明书 for BDY FL Thalidomide

分析证书/产品说明书
化学品安全技术说明书

参考文献 for BDY FL Thalidomide

参考文献是支持产品生物活性的出版物。

Lin et al (2021) General stepwise approach to optimize a TR-FRET assay for characterizing the BRD/PROTAC/CRBN ternary complex. ACS Pharmacol.Transl.Sci. 4 941 PMID: 33860212

Lin et al (2020) Development of BODIPY FL Thalidomide as a high-affinity fluorescent probe for cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer assay. Bioconjug.Chem. 31 2564 PMID: 33070611

If you know of a relevant reference for BDY FL Thalidomide, please let us know.

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