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Submit ReviewBegacestat
Discontinued Product
4283 has been discontinued.
说明： γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
别名： GSI-953
化学名： 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for Begacestat
Begacestat is a γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for Begacestat
| 分子量 | 391.74 |
| 公式 | C9H8ClF6NO3S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 769169-27-9 |
| PubChem ID | 11269353 |
| InChI Key | PSXOKXJMVRSARX-SCSAIBSYSA-N |
| Smiles | ClC1=CC=C(S(N[C@H](CO)C(C(F)(F)F)C(F)(F)F)(=O)=O)S1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Begacestat
参考文献 for Begacestat
参考文献是支持产品生物活性的出版物。
Mayer et al (2008) Discovery of begacestat, a Notch-1-sparing gamma secretase inhibitor for the treatment of Alzheimer's disease. J.Med.Chem. 51 7348 PMID: 19012391
Martone et al (2009) Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's disease. J.Pharmacol.Exp.Ther. 331 598 PMID: 19671883
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关键词: Begacestat, Begacestat supplier, GSI953, Begacestat, pfizer, gamma, gamma-secretase, γ, g-secretase, inhibitors, inhibits, APP, amyloid, precursor, proteins, notch, AB40, Abeta40, Aβ40, AB42, Abeta42, Aβ42, amyloidbeta, amyloidb, amyloidβ, GSI-953, Gamma-Secretase, Amyloid, Beta, Peptides, 4283, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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