Benzamil

Cat. No. 3380 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

化学名： N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Benzamil

Benzamil is a Na⁺/Ca²⁺ exhanger (NCX) inhibitor (IC₅₀ ~ 100 nM); TRPP3 channel blocker (IC₅₀ = 1.1 μM for inhibition of Ca²⁺-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

化合物库 for Benzamil

Benzamil is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Benzamil

分子量	356.21
公式	C₁₃H₁₄ClN₇O.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	161804-20-2
PubChem ID	5702295
InChI Key	ZNWMRWWNJBXNKJ-UHFFFAOYSA-N
Smiles	NC1=C(Cl)N=C(C(NC(NCC2=CC=CC=C2)=N)=O)C(N)=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Benzamil

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	35.62	100
	water	3.56	10

制备储备液 for Benzamil

以下数据基于产品分子量 356.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.04 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.4 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

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产品说明书 for Benzamil

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Benzamil

参考文献是支持产品生物活性的出版物。

Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

Fischer et al (2002) Characterization of a Na⁺-Ca²⁺ exchanger in podocytes. Nephrol.Dial.Transplant. 17 1742 PMID: 12270979

Page et al (2007) Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain 133 150 PMID: 17467171

If you know of a relevant reference for Benzamil, please let us know.

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