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BHPI

Cat. No. 6116 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： ERα antagonist; also activates unfolded protein response; active in vivo
化学名： 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BHPI

BHPI is an estrogen receptor (ER) α inhibitor. Inhibits proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. Induces sustained activation of the unfolded protein response. Active in vivo.

化合物库 for BHPI

BHPI is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BHPI

分子量 331.36
公式 C21H17NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 56632-39-4
PubChem ID 3860640
InChI Key FABLAHMQSQFDHR-UHFFFAOYSA-N
Smiles CC1=CC=CC2=C1NC(C2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BHPI

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.14 100
ethanol 33.14 100

制备储备液 for BHPI

以下数据基于产品分子量 331.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for BHPI

参考文献是支持产品生物活性的出版物。

Andruska et al (2015) Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc.Natl.Acad.Sci.U.S.A. 112 4737 PMID: 25825714

If you know of a relevant reference for BHPI, please let us know.

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关键词: BHPI, BHPI supplier, estrogen, receptor, alpha, ER, α, inhibitor, UPR, unfolded, protein, response, Estrogen, (GPER), Receptors, Other, stress/UPR, 6116, Tocris Bioscience

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Pathways for BHPI

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.