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BI 6015

Cat. No. 4641 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Hepatocyte nuclear factor 4α (HNF4α) antagonist
化学名： 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BI 6015

BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.

化合物库 for BI 6015

BI 6015 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BI 6015

分子量 331.35
公式 C15H13N3O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 93987-29-2
PubChem ID 3269393
InChI Key ILVCPQPMRPHZSG-UHFFFAOYSA-N
Smiles CC2=NC1=CC=CC=C1N2S(C3=C(C)C=CC([N+]([O-])=O)=C3)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BI 6015

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.63 20

制备储备液 for BI 6015

以下数据基于产品分子量 331.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 15.09 mL 75.45 mL 150.9 mL
1 mM 3.02 mL 15.09 mL 30.18 mL
2 mM 1.51 mL 7.54 mL 15.09 mL
10 mM 0.3 mL 1.51 mL 3.02 mL

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参考文献 for BI 6015

参考文献是支持产品生物活性的出版物。

Kiselyuk et al (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human Ins promoter. Chem.Biol. 19 806 PMID: 22840769

If you know of a relevant reference for BI 6015, please let us know.

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关键词: BI 6015, BI 6015 supplier, BI6015, Hepatocyte, nuclear, factor, 4, alpha, HNF4a, HNF4α, antagonists, DNA, binding, cancer, Other, Transcription, Factors, 4641, Tocris Bioscience

3 篇 BI 6015 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BI 6015 的部分引用包括：

Levy et al (2016) Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection Nature Chemical Biology 12 1037 PMID: 27723751

David J et al (2023) Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice. Sci Rep 13 7752 PMID: 37173326

Hu et al (2018) Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma. Front Pharmacol 9 1150 PMID: 30405404

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