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Submit ReviewBIMU 8
说明： Potent 5-HT4 agonist
化学名： 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for BIMU 8
BIMU 8 is a potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
化合物库 for BIMU 8
BIMU 8 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BIMU 8
| 分子量 | 378.9 |
| 公式 | C19H26N4O2.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 134296-40-5 |
| PubChem ID | 5311028 |
| InChI Key | NQYXXIUVFVOJCX-XZPOUAKSSA-N |
| Smiles | [H][C@]12CC[C@](CC(NC(N3C(C=CC=C4)=C4N(C(C)C)C3=O)=O)C2)([H])N1C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BIMU 8
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 28.42 | 75 | |
| DMSO | 37.89 | 100 |
制备储备液 for BIMU 8
以下数据基于产品分子量 378.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.64 mL | 13.2 mL | 26.39 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.28 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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产品说明书 for BIMU 8
参考文献 for BIMU 8
参考文献是支持产品生物活性的出版物。
Pellissier et al (2009) Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 75 982 PMID: 19168624
Schaus et al (1998) Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 41 1943 PMID: 9599243
If you know of a relevant reference for BIMU 8, please let us know.
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关键词: BIMU 8, BIMU 8 supplier, BIMU8, 5-hydroxytryptamine, 4, 5HT4, receptors, 5-HT4, agonists, serotonin, serotonergic, Receptors, 4374, Tocris Bioscience
7 篇 BIMU 8 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BIMU 8 的部分引用包括：
James L et al (2018) Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. J Anim Sci 96 1570-1578 PMID: 29471490
Lucie P et al (2013) Serotonin type 4 receptor dimers. Methods Cell Biol 117 123-39 PMID: 24143975
Daniel et al (2021) Serotonin receptor 4 regulates hippocampal astrocyte morphology and function. Glia 69 872-889 PMID: 33156956
Carolina da Silveira et al (2021) Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish. Elife 10 PMID: 33720013
Andre et al (2021) The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons. J Cell Sci 134 PMID: 33536244
Wang et al (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions Scientific Reports 6 37336 PMID: 27874067
House et al (2015) Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. PLoS One 29 323 PMID: 25342126
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BIMU 8 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.