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说明： Red fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 646; fluorogenic; photostable
化学名： 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-5-(((1-((3R,5S)-5-(((S)-1-carboxy-2-(4-((pyrrolidine-1-carbonyl)oxy)phenyl)ethyl)carbamoyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)benzoate
纯度： ≥90% (HPLC)
生物活性 for BOP-JF646
BOP-JF646 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP (Cat. No. 6047) conjugated to Janelia Fluor® 646 (Cat. No. 6148). Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 655 nm; emission maximum = 672 nm.
Scientific Data
Application of BOP-JF549 in Immortalized Human Keratinocyte Cells. Immortalized human keratinocytes expressing a GFP-tagged alpha 4 integrin were incubated with 10 μm BOP-Janelia Fluor® 568. Cells were incubated at 37°C and imaged using Nikon A1R confocal microscope. Scale bar = 10 μm.Image kindly provided by Willow Hight-Warburton; Kings College London.
Optical Data for BOP-JF646
| Emission Color | Red |
|---|---|
| Brightness | |
| λabs | 655 nm |
| λem | 672 nm |
| Closest Laser line | 647 nm |
| Application | Flow Cytometry, Confocal Microscopy, Super Resolution Microscopy (SRM) |
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技术数据 for BOP-JF646
| 分子量 | 1090.3 |
| 公式 | C57H59N9O10SSi |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| InChI Key | NHBQNNGTILNQPL-HXFFEZBUSA-N |
| Smiles | OC([C@@H](NC([C@@H]1C[C@@H](N2C=C(CNC(C3=CC=C(C([O-])=O)C(C(C4=CC=C(N5CCC5)C=C4[Si]6(C)C)=C(C=C/7)C6=CC7=[N+]8CCC\8)=C3)=O)N=N2)CN1S(=O)(C9=CC=CC=C9)=O)=O)CC%10=CC=C(C=C%10)OC(N%11CCCC%11)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BOP-JF646
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关键词: BOP-JF646, BOP-JF646 supplier, Fluorescent, dual, α9β1/α4β1, integrins, inhibitors, BOP, labels, stains, HSC, progenitors, hematopoietic, haematopoietic, stem, cells, Integrins, Stem, Cell, Signaling, Integrin, Probes, Hematopoietic, Cells, 6997, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product Guide
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