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BTB1

Cat. No. 5399 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective and ATP-competitive Kif18A inhibitor
化学名： 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
纯度： ≥99% (HPLC)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BTB1

BTB1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.

技术数据 for BTB1

分子量 297.71
公式 C12H8ClNO4S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 86030-08-2
PubChem ID 291461
InChI Key VZDUQPHKUBZMLW-UHFFFAOYSA-N
Smiles ClC1=CC([N+]([O-])=O)=C(S(C2=CC=CC=C2)(=O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BTB1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.77 100
ethanol 5.95 20

制备储备液 for BTB1

以下数据基于产品分子量 297.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.79 mL 33.59 mL
5 mM 0.67 mL 3.36 mL 6.72 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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参考文献 for BTB1

参考文献是支持产品生物活性的出版物。

Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554 PMID: 25402598

Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072 PMID: 19856362

If you know of a relevant reference for BTB1, please let us know.

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关键词: BTB1, BTB1 supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Kinesin, Mitosis, 5399, Tocris Bioscience

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