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BTS

Cat. No. 1870 5 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective inhibitor of skeletal muscle myosin II ATPase activity
化学名： 4-Methyl-N-(phenylmethyl)benzenesulfonamide
纯度： ≥99% (HPLC)
说明书
引用文献 (5)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BTS

BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

化合物库 for BTS

BTS is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BTS

分子量 261.34
公式 C14H15NO2S
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1576-37-0
PubChem ID 95801
InChI Key WTHKAJZQYNKTCJ-UHFFFAOYSA-N
Smiles CC1=CC=C(C=C1)S(=O)(=O)NCC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BTS

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 18.29 70
DMSO 26.13 100

制备储备液 for BTS

以下数据基于产品分子量 261.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.13 mL 38.26 mL
5 mM 0.77 mL 3.83 mL 7.65 mL
10 mM 0.38 mL 1.91 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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参考文献 for BTS

参考文献是支持产品生物活性的出版物。

Cheung et al (2001) A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 4 83 PMID: 11744924

Ramachandran et al (2003) Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 55 61 PMID: 12673599

Shaw et al (2003) Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42 6128 PMID: 12755615

If you know of a relevant reference for BTS, please let us know.

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关键词: BTS, BTS supplier, Selective, inhibitors, inhibits, skeletal, muscle, myosin, II, ATPase, activity, Myosin, 1870, Tocris Bioscience

5 篇 BTS 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BTS 的部分引用包括：

Magown et al (2015) Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy. Nat Commun 6 8506 PMID: 26460719

Thorne et al (2012) Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem Biol 19 1060 PMID: 22921073

Boncompagni et al (2010) The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell 9 958 PMID: 20961389

Lee et al (2015) Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. FASEB J 5 4 PMID: 25717360

Ferreira et al (2018) Early redox activities modulate Xenopus tail regeneration. Nat Commun 9 4296 PMID: 30327466

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