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BTZO 1

Cat. No. 4204 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： MIF binder
化学名： 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BTZO 1

BTZO 1 binds macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and activates antioxidant response element (ARE)-mediated gene expression. BTZO 1 suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro and is cardioprotective.

External Portal Information for BTZO 1

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of BTZO 1 is reviewed on chemicalprobes.org and the SGC website.

化合物库 for BTZO 1

BTZO 1 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BTZO 1

分子量 240.28
公式 C13H8N2OS
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 99420-15-2
PubChem ID 9837640
InChI Key GBAKVEWPYUIGHN-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BTZO 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.81 20 温和加热

制备储备液 for BTZO 1

以下数据基于产品分子量 240.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 20.81 mL 104.05 mL 208.09 mL
1 mM 4.16 mL 20.81 mL 41.62 mL
2 mM 2.08 mL 10.4 mL 20.81 mL
10 mM 0.42 mL 2.08 mL 4.16 mL

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参考文献 for BTZO 1

参考文献是支持产品生物活性的出版物。

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282 PMID: 21168764

If you know of a relevant reference for BTZO 1, please let us know.

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关键词: BTZO 1, BTZO 1 supplier, BTZO1, mif, macrophage, migration, inhibitory, factors, binders, binds, cardioprotective, Cytokines, 4204, Tocris Bioscience

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