BzATP triethylammonium salt

Name: BzATP triethylammonium salt
Brand: Tocris Bioscience
SKU: 3312
Rating: 4.5 (2 reviews)

Cat. No. 3312 6 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Photoaffinity label for ATPase; also P2X₇ agonist and P2X₁/P2Y₁ partial agonist

化学名： 2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate tri(triethylammonium) salt

纯度： ≥95% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BzATP triethylammonium salt

BzATP triethylammonium salt is a prototypic P2X₇ receptor agonist (EC₅₀ values are 3.6, 7 and 285 μM for rat, human and mouse receptors respectively). Exhibits 5 - 10 fold greater potency than ATP. Exhibits partial agonist activity at P2X₁ (pEC₅₀ = 8.7) and P2Y₁ receptors and can be used as a photoaffinity label for ATPase.

This compound is a mixture of isomers.

技术数据 for BzATP triethylammonium salt

分子量	1018.97
公式	C₂₄H₂₄N₅O₁₅P₃.C₁₈H₄₅N₃
储存	Store at -20°C
纯度	≥95% (HPLC)
PubChem ID	71308559
InChI Key	HVOVBTNCGADRTH-WBLDMZOZSA-N
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@H]3O)C=N2)=NC=N1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.NC6=C7C(N([C@@H]8O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]8OC(C9=CC=C(C(C%10=CC=CC=C%10)=O)C=C9)=O)C=N7)=NC=N6.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BzATP triethylammonium salt

溶解性	Soluble in water (supplied pre-dissolved at a concentration of 5mM)

产品说明书 for BzATP triethylammonium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BzATP triethylammonium salt

参考文献是支持产品生物活性的出版物。

Williams and Coleman (1982) Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate. J.Biol.Chem. 257 2834 PMID: 6460764

Zhong et al (1998) Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br.J.Pharmacol. 125 771 PMID: 9831914

Michel et al (2001) Serum constituents can effect 2'- & 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X₇ receptors. Br.J.Pharmacol. 132 1501 PMID: 11264244

Young et al (2007) Amino acid residues in the P2X₇ receptor that mediate differential sensitivity fo ATP and BzATP. Mol.Pharmacol. 71 92 PMID: 17032903

Surprenant et al (1996) The cytolytic P_2Z receptor for extracellular ATP identified as a P_2X receptor (P2X₇). Science. 272 735 PMID: 8614837

If you know of a relevant reference for BzATP triethylammonium salt, please let us know.

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关键词: BzATP triethylammonium salt, BzATP triethylammonium salt supplier, P2Y1, partial, agonists, P2X7, P2X1, Photoaffinity, label, ATPases, P2X1/P2Y1, Receptors, Purinergic, purinoceptors, 112898-15-4, P2X, P2Y, Other, Photoactivatable, cross-linking, probes, 3312, Tocris Bioscience

6 篇 BzATP triethylammonium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BzATP triethylammonium salt 的部分引用包括：

Karmakar et al (2016) Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat.Commun. 7 10555 PMID: 26877061

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Sci Rep 305 F396 PMID: 23720349

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730

Nörenberg et al (2012) Positive allosteric modulation by iverm. of human but not murine P2X7 receptors. Br J Pharmacol 167 48 PMID: 22506590

Pronin et al (2019) Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Front Mol Neurosci 12 36 PMID: 30930743

Woehrle et al (2010) Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol 88 1181 PMID: 20884646

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