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Submit ReviewC 87
说明： TNF-α inhibitor
化学名： 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
纯度： ≥98% (HPLC)
生物活性 for C 87
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.
技术数据 for C 87
| 分子量 | 502.93 |
| 公式 | C24H15ClN6O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 332420-90-3 |
| PubChem ID | 5756872 |
| InChI Key | VELQTEBILFDDQX-SLMZUGIISA-N |
| Smiles | O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for C 87
参考文献 for C 87
参考文献是支持产品生物活性的出版物。
Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219
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关键词: C 87, C 87 supplier, TNF-alpha, TNF-a, TNF-α, tumor, necrosis, factor, inflammation, inhibitors, C87, 1609281-56-2, inhibits, Cytokines, 5484, Tocris Bioscience
2 篇 C 87 的引用文献
引用文献是使用了 Tocris 产品的出版物。 C 87 的部分引用包括：
Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752
Markus et al (2019) Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization. J Biol Chem 294 4368-4380 PMID: 30670595
C 87 的评论
平均评分: 4.5 (基于 2 条评论。)
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Combinatorial treatments.
By
MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human
Combinatorial treatments of the TNF-alpha inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro.
Works Well..
By
Purnima Gupta on 01/10/2018
分析类型： In Vitro
种属： Mouse
Used in Fibroblast cytotoxicity assay
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.