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C3bot (154-182)

Cat. No. 4123 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4123 has been discontinued.

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说明： Neurotrophic fragment of clostridial C3 protein
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生物活性 技术数据 说明书 参考文献

生物活性 for C3bot (154-182)

C3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.

技术数据 for C3bot (154-182)

分子量 3058.54
公式 C137H221N37O40S
序列 VAKGSKAGYIDPISAFAGQLEMLLPRHST
储存 Store at -20°C
CAS Number 1246280-79-4
PubChem ID 90488913
InChI Key COZZQWVNMFWMBN-QMBBDSMRSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for C3bot (154-182)

分析证书/产品说明书
化学品安全技术说明书

参考文献 for C3bot (154-182)

参考文献是支持产品生物活性的出版物。

Holtje et al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115 PMID: 19047066

Boato et al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 123 1652

Just et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383 247

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关键词: C3bot (154-182), C3bot (154-182) supplier, clostridium, clostridial, C3, protein, neurotrophic, axon, dendrite, outgrowth, transferase-deficient, peptide, fragment, spinal, cord, injury, injuries, c3, bot154-182, Neuronal, Metabolism, 4123, Tocris Bioscience

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