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CAM 833

Cat. No. 7457 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective orthosteric inhibitor of the BRCA2-RAD51 interaction
化学名： N-(2-((2S,4R)-2-(((S)-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
纯度： ≥98% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CAM 833

CAM 833 a selective orthosteric inhibitor of the BRCA2-RAD51 interaction (Kd of 366 nM; IC50 of 6 μM). CAM 833 has no significant off-target interactions when screened at 10 μM in the Cerep ExpresSPanel. It inhibits DNA recombinase RAD51-mediated homologous recombination through binding to RAD51 at the same site as the BRCA2 FxxA motif. In cells, CAM 833 suppresses the assembly of RAD51 into damage-induced filaments at the sites of DNA damage. CAM 833 potentiates radiation-induced cytotoxicity and poly-ADP ribose polymerase (PARP)1 inhibitor-induced growth suppression in BRCA2-wild-type cells. The product is metabolically stable, does not significantly inhibit CYP450 enzymes, and is suitable for in vivo investigation.

技术数据 for CAM 833

分子量 528.97
公式 C26H26ClFN4O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2758364-02-0
InChI Key PMUWBFKMLGLUTF-KNUWZQJKSA-N
Smiles FC1=CC2=CC=C(N=C2C=C1)C(NCC(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=C(C=C(C=C4)OC)Cl)C)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CAM 833

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.9 100
ethanol 2.64 5

制备储备液 for CAM 833

以下数据基于产品分子量 528.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for CAM 833

参考文献是支持产品生物活性的出版物。

Scott et al (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem.Biol. 28 835 PMID: 33662256

If you know of a relevant reference for CAM 833, please let us know.

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关键词: CAM 833, CAM 833 supplier, orthosteric, inhibitor, BRCA2, RAD51, interaction, DNA-damage, cancer, PARP1, selective, DNA,, RNA, and, Protein, Synthesis, 7457, Tocris Bioscience

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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