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Cardamonin

Cat. No. 2509 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibitor of NF-κB activation; anti-inflammatory
化学名： (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cardamonin

Cardamonin is a chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.

化合物库 for Cardamonin

Cardamonin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Cardamonin

分子量 270.28
公式 C16H14O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 19309-14-9
PubChem ID 641785
InChI Key NYSZJNUIVUBQMM-BQYQJAHWSA-N
Smiles OC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cardamonin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.03 100
ethanol 5.41 20

制备储备液 for Cardamonin

以下数据基于产品分子量 270.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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产品说明书 for Cardamonin

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Cardamonin

参考文献是支持产品生物活性的出版物。

Lee et al (2006) Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271 PMID: 16183703

Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188 PMID: 16650843

Israf et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673 PMID: 16777230

If you know of a relevant reference for Cardamonin, please let us know.

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关键词: Cardamonin, Cardamonin supplier, Nf-kappaB, NF-kB, NF-κB, inhibitors, activation, inhibits, anti-inflammatory, transcription, factors, nuclear, factor, kappa, B, signaling, signalling, NF-kB/IkB, 2509, Tocris Bioscience

3 篇 Cardamonin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cardamonin 的部分引用包括：

Kim et al (2016) Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. EBioMedicine 7 100 PMID: 27322464

Jia et al (2015) β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22 298 PMID: 25257174

Yadav et al (2012) Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins. Br J Pharmacol 165 741 PMID: 21797841

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Cardamonin 的评论

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Pathways for Cardamonin

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.