CCMI

Cat. No. 3837 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Positive allosteric modulator of α7 nAChRs

别名： XY 4083

化学名： [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CCMI

CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC₅ currents (EC₅₀ = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

化合物库 for CCMI

CCMI is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CCMI

分子量	388.25
公式	C₁₉H₁₅Cl₂N₃O₂
储存	Store at -20°C
CAS Number	917837-54-8
PubChem ID	67042344
InChI Key	VMAKIACTLSBBIY-UHFFFAOYSA-N
Smiles	CC1=NOC(=C1)C(=CNC1=CC=C(Cl)C=C1)C(=O)NC1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CCMI

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	38.83	100
	ethanol	3.88	10

制备储备液 for CCMI

以下数据基于产品分子量 388.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.88 mL	25.76 mL
5 mM	0.52 mL	2.58 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for CCMI

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CCMI

参考文献是支持产品生物活性的出版物。

Gronlien et al (2007) Distinct profiles of α₇ nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715 PMID: 17565004

Hu et al (2009) Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857 PMID: 20050184

Ng et al (2007) Nootropic α7 nicotinic receptor allosteric modulator derived from GABA_A receptor modulators. Proc.Natl.Acad.Sci.U.S.A. 104 8059 PMID: 17470817

If you know of a relevant reference for CCMI, please let us know.

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关键词: CCMI, CCMI supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, Nicotinic, Receptors, Acetylcholine, XY4083, PAM, XY, 4083, (a7), 3837, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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