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CCT 369260

Cat. No. 7799 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Molecular glue; induces degradation of BCL6
化学名： rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CCT 369260

CCT 369260 acts as a potent BCL6 molecular glue Degrader (IC50 = 54 nM). It reduces BCL6 levels in a lymphoma xenograft mouse model. CCT 369260 is orally bioavailable.

技术数据 for CCT 369260

分子量 509
公式 C24H31ClF2N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2253878-44-1
PubChem ID 135386938
InChI Key VFNPUAOAEFMXQI-GASCZTMLSA-N
Smiles CC(C)(O)CCN1C2=CC(NC3=NC(N4C[C@@H](C(F)([C@@H](C4)C)F)C)=NC=C3Cl)=CC=C2N(C1=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CCT 369260

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.45 50

制备储备液 for CCT 369260

以下数据基于产品分子量 509。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.93 mL 19.65 mL 39.29 mL
2.5 mM 0.79 mL 3.93 mL 7.86 mL
5 mM 0.39 mL 1.96 mL 3.93 mL
25 mM 0.08 mL 0.39 mL 0.79 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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参考文献 for CCT 369260

参考文献是支持产品生物活性的出版物。

Bellenie et al (2020) Achieving in vivo target depletion through the discovery and optimization of Benzimidazolone BCL6 degraders. J.Med.Chem. 2020 63 PMID: 32275432

If you know of a relevant reference for CCT 369260, please let us know.

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关键词: CCT 369260, CCT 369260 supplier, CCT369260, molecular, glue, proteasomal, degraders, inhibitors, inhibit, inhibition, BCL6, ubiquitination, orally, bioavailable, in, vivo, Molecular, Glues, Bcl-2, Family, 7799, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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