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Submit ReviewCELT-426
说明： Potent and partially selective hD2 dopamine receptor fluorescent antagonist
纯度： ≥95% (HPLC)
生物活性 for CELT-426
CELT-426 is a potent and partially selective fluorescent hD2 dopamine receptor antagonist (Ki values are 89.3 nM, 194.8 nM, and 263.6 nM for D2, D3, and D4 dopamine receptors respectively in radioligand binding assay). CELT-426 can be used as a fluorescent dopamine receptor probe for fluorescence binding assays, live cell imaging, flow cytometry, and fluorescence polarization assays. It is a suitable replacement for GPCR radiolabeling ligands. Excitation and emission maxima (λ) are 560 and 571 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
Add 62 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as working concentration.
Scientific Data
Competition Assay
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Application of CELT-426 in high content screening assay. Competition binding assay between CELT-426 (100 nM) and increasing concentrations of haloperidol (Catalog # 0931) in live adherent CHO cells expressing hD2.
Application of CELT-426 in fluorescence polarization assay. Human dopamine D2 receptor was isolated from CHO cells by membrane preparation and incubated with CELT-426 (100 nM). Haloperidol (Catalog # 0931) was added across a range of concentrations, and the binding affinity (KD = 3 nM) determined by fluorescence polarization.
许可信息
Sold under license from Celtarys Research
Optical Data for CELT-426
| Emission Color | Yellow |
|---|---|
| λabs | 560 nm |
| λem | 571 nm |
| Closest Laser line | 561 nm |
| Application | Fluorescence polarization, Confocal microscopy, Flow Cytometry, High-content screening, |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
技术数据 for CELT-426
| 分子量 | 1615.85 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CELT-426
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关键词: CELT-426, CELT-426 supplier, CELT-426, hD2, dopamine, receptors, fluorescent, antagonist, probe, Fluorescent, Receptor, Probes, D2, Receptors, TR-FRET, and, FP, Assay, Reagents, 7955, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product Guide
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- Fluorescent Dyes, including dyes for flow cytometry
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