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说明： TAF1 inhibitor
化学名： N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for CeMMEC1
CeMMEC1 is a TAF1 inhibitor (Kd = 1.8 μM, IC50 = 900 nM). CeMMEC1 impairs cell viability in combination with (+)-JQ1 (Cat. No. 4499) and inhibits proliferation of THP-1 and H23 lung adenocarcinoma cells.
化合物库 for CeMMEC1
CeMMEC1 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for CeMMEC1
| 分子量 | 336.35 |
| 公式 | C19H16N2O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 440662-09-9 |
| PubChem ID | 24152379 |
| InChI Key | PEOQAZBGLOADFJ-UHFFFAOYSA-N |
| Smiles | CN1C=C(C(=O)NC2=CC=C3OCCOC3=C2)C2=CC=CC=C2C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CeMMEC1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.63 | 100 |
制备储备液 for CeMMEC1
以下数据基于产品分子量 336.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.73 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for CeMMEC1
参考文献 for CeMMEC1
参考文献是支持产品生物活性的出版物。
Sdelci et al (2016) Mapping the chemical chromatin reactivation landscape identifies BRD 4-TAtaF1 cross-talk. Nat.Chem.Biol. 12 504 PMID: 27159579
If you know of a relevant reference for CeMMEC1, please let us know.
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关键词: CeMMEC1, CeMMEC1 supplier, TAF1, bromodomain, inhibits, inhibitors, Bromodomains, 7139, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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