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Submit ReviewCGP 36216 hydrochloride
说明： GABAB antagonist; displays activity at presynaptic receptors
化学名： (3-Aminopropyl)ethylphosphinic acid hydrochloride
纯度： ≥99% (HPLC)
生物活性 for CGP 36216 hydrochloride
CGP 36216 hydrochloride is a selective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.
化合物库 for CGP 36216 hydrochloride
CGP 36216 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CGP 36216 hydrochloride
| 分子量 | 187.6 |
| 公式 | C5H14NO2P.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1781834-71-6 |
| PubChem ID | 90488815 |
| InChI Key | CFQFXUJBWMPODB-UHFFFAOYSA-N |
| Smiles | O=P(CC)(CCCN)O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CGP 36216 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.76 | 100 | |
| DMSO | 18.76 | 100 |
制备储备液 for CGP 36216 hydrochloride
以下数据基于产品分子量 187.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.33 mL | 26.65 mL | 53.3 mL |
| 5 mM | 1.07 mL | 5.33 mL | 10.66 mL |
| 10 mM | 0.53 mL | 2.67 mL | 5.33 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.07 mL |
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产品说明书 for CGP 36216 hydrochloride
参考文献 for CGP 36216 hydrochloride
参考文献是支持产品生物活性的出版物。
Ong et al (2001) CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur.J.Pharmacol. 415 191 PMID: 11274998
Froestl et al (1995) Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J.Med.Chem. 38 3313 PMID: 7650685
If you know of a relevant reference for CGP 36216 hydrochloride, please let us know.
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关键词: CGP 36216 hydrochloride, CGP 36216 hydrochloride supplier, CGP36216, hydrochloride, gabab, antagonists, presynaptic, selective, GABAB, Receptors, 3219, Tocris Bioscience
1 篇 CGP 36216 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGP 36216 hydrochloride 的部分引用包括：
Chen et al (2015) Morphine disinhibits glutamatergic input to VTA DA neurons and promotes DA neuron excitation. J Neurosci 4 PMID: 26208338
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