CGP 71683 hydrochloride

Cat. No. 2199 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly selective and potent non-peptide NPY Y₅ receptor antagonist

化学名： N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (6)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CGP 71683 hydrochloride

CGP 71683 hydrochloride is an extremely selective, non-peptide NPY Y₅ receptor antagonist. Displays > 1000-fold selectivity over Y₁, Y₂ and Y₄ receptors; IC₅₀ values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y₅, Y₁, Y₂ and Y₄ receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

化合物库 for CGP 71683 hydrochloride

CGP 71683 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CGP 71683 hydrochloride

分子量	512.07
公式	C₂₆H₂₉N₅O₂S.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	192322-50-2
PubChem ID	9849276
InChI Key	DIQDKUNCSVFGHH-UHFFFAOYSA-N
Smiles	NC1=NC(NC[C@H]3CC[C@H](CNS(=O)(C4=CC=CC5=C4C=CC=C5)=O)CC3)=NC2=C1C=CC=C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGP 71683 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	51.21	100

制备储备液 for CGP 71683 hydrochloride

以下数据基于产品分子量 512.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.76 mL	19.53 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
10 mM	0.2 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

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产品说明书 for CGP 71683 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CGP 71683 hydrochloride

参考文献是支持产品生物活性的出版物。

Criscione et al (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y₅ receptor. J.Clin.Invest. 102 2136 PMID: 9854049

Dumont et al (2000) Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). Can.J.Physiol.Pharmacol. 78 116 PMID: 10737674

Lecklin et al (2002) Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029 PMID: 11959807

If you know of a relevant reference for CGP 71683 hydrochloride, please let us know.

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关键词: CGP 71683 hydrochloride, CGP 71683 hydrochloride supplier, selective, potent, non-peptide, NPY, Y5, receptor, antagonists, Neuropeptide, Y, Receptors, CGP71683, hydrochloride, neuropeptides, 2199, Tocris Bioscience

6 篇 CGP 71683 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CGP 71683 hydrochloride 的部分引用包括：

Tilan et al (2013) Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget 4 2487 PMID: 24318733

Reidelberger et al (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab 304 E944 PMID: 23482449

Han et al (2012) Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system. PLoS One 7 e36609 PMID: 22570731

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Am J Physiol Cell Physiol 488 172 PMID: 22801496

Demorrow et al (2011) Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. Nature 300 C1078 PMID: 21270292

Lu et al (2011) Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. J Biol Chem 286 27494 PMID: 21680731

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